EUCTR2020-000982-18-NO
A clinical study to evaluate the efficacy of different anti-viral drugs in SARS-CoV-2 infected patients (COVID-19)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Unclear
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (4)
  2. Usual Care
  3. Remdesivir
  4. Hydroxychloroquine
  1. Comparison (2)
  2. Hydroxychloroquine
  3. Remdesivir
  1. Outcome (6)
  2. Length Of Stay
  3. Infection
  4. Organ dysfunction
  5. SARS-CoV-2 Virus
  6. Death
  7. Mechanical ventilation
References (1)
NCT04390594
Multicentre, Open Label, Randomised, Adaptative Clinical Trial of Efficacy and Safety of Treatment Regimens in Adult COVID-19 Patients in Senegal
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  6. Child
  1. Intervention (2)
  2. Azithromycin
  3. Hydroxychloroquine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Serious Adverse Event
  3. Hospitalization
  4. SARS-CoV-2 Virus
  5. Viral load
  6. Oxygen Therapy
  7. Sequential Organ Failure Assessment Score
References (1)
NCT04321616
The (Norwegian) NOR Solidarity Multicenter Trial on the Efficacy of Different Anti-viral Drugs in SARS-CoV-2 Infected Patients
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (4)
  2. Usual Care
  3. Remdesivir
  4. Hydroxychloroquine
  1. Comparison (2)
  2. Remdesivir
  3. Hydroxychloroquine
  1. Outcome (7)
  2. Infection
  3. Length of ICU Stay
  4. Death
  5. Organ dysfunction
  6. SARS-CoV-2 Virus
  7. Length Of Stay
  8. Mechanical ventilation
References (1)
NCT04338698
Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (11)
  2. Azithromycin
  3. Oseltamivir
  4. Hydroxychloroquine
  5. Hydroxyquinine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (2)
  2. COVID-19
  3. COVID-19 Ordinal Outcomes Scale
References (3)
NCT04361461
Hydroxychloroquine or Hydroxychloroquine Associated With Azithromycin for Inpatients With Moderate or Severe Lung Disease Due to SARS-CoV-2 (COVID-19)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Coronavirus Infection
  4. COVID-19
  5. SARS-CoV-2 Virus
  6. Adult
  7. Aged (65+)
  1. Intervention (1)
  2. Hydroxychloroquine Sulfate
  1. Comparison (2)
  2. Azithromycin
  3. Hydroxychloroquine Sulfate
  1. Outcome (5)
  2. All Cause Mortality
  3. Treatment discontinued
  4. Hospitalization
  5. Mechanical ventilation
  6. Ordinal Scale
References (1)
Pianta 2020
Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Non-randomised
  1. Population (1)
  2. COVID-19
  1. Intervention (3)
  2. Acetic Acid
  3. Hydroxychloroquine
  4. Inhaled
  1. Comparison (2)
  2. Lopinavir And Ritonavir
  3. Hydroxychloroquine
  1. Outcome (1)
  2. Symptoms improving
References (1)
NCT04332835
Convalescent Plasma for Patients With COVID-19: A Randomized, Open Label, Parallel, Controlled Clinical Study
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (0)
  1. Intervention (2)
  2. Convalescent plasma
  3. Hydroxychloroquine
  1. Comparison (2)
  2. Hydroxychloroquine
  1. Outcome (8)
  2. Viral load
  3. Clinical status
  4. Death
  5. Length of ICU Stay
  6. Immunoglobulin G antibody to SARS-CoV-2
  7. Admission to Intensive Care Unit
  8. Antibodies
  9. Mechanical ventilation
References (1)
NCT04347980
Dexamethasone Combined With Hydroxychloroquine Compared to Hydroxychloroquine Alone for Treatment of Severe Acute Respiratory Distress Syndrome Induced by Coronavirus Disease 19 (COVID-19): a Multicentre, Randomised Controlled Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Acute Respiratory Distress Syndrome
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Dexamethasone
  3. Hydroxychloroquine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (9)
  2. Bacteremia
  3. Nosocomial Pneumonia
  4. Death
  5. Tracheostomy Tube
  6. Intensive Care
  7. Prone Positioning
  8. Mechanical ventilation
  9. Extracorporeal Membrane Oxygenation
References (1)
NCT04351191
Use and Dosage of Hydroxychloroquine and Chloroquine to Convert Symptomatic RT-PCR Positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Infectious Disease 2019 (COVID-19) Patients to RT- PCR-Negative as a Means to Reduce Hospitalization Rate
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (5)
  2. Male and Female
  3. COVID-19
  4. Adult
  1. Intervention (6)
  2. Hydroxychloroquine Sulfate
  3. Therapeutic Intent
  4. Hospital
  1. Comparison (8)
  2. Hydroxychloroquine Sulfate
  3. Chloroquine
  4. Usual Care
  5. Placebo
  6. Therapeutic Intent
  7. Hospital
  1. Outcome (3)
  2. Death
  3. Disease Progression
  4. SARS-CoV-2 RT-PCR
References (1)
IRCT20200324046850N3 // U07
The effect of naproxen on the healing process of patients with COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. COVID-19
  4. Chest CT
  5. Adult
  6. Aged (65+)
  7. Child
  1. Intervention (3)
  2. Naproxen
  3. Lopinavir And Ritonavir
  4. Hydroxychloroquine Sulfate
  1. Comparison (3)
  2. Hydroxychloroquine Sulfate
  3. Lopinavir And Ritonavir
  4. Placebo
  1. Outcome (4)
  2. Cough
  3. Fever
  4. Night Sweats
  5. Chill
References (1)
IRCT20200403046926N1
The effect of SOVODAK in the treatment of COVID-19 patients
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (12)
  2. Male and Female
  3. COVID-19
  4. Infant
  5. Adult
  6. Aged (65+)
  7. Child
  1. Intervention (6)
  2. Naproxen
  3. Pantoprazole
  4. Azithromycin
  5. Hydroxychloroquine
  6. Sofosbuvir
  7. Daclatasvir
  1. Comparison (4)
  2. Hydroxychloroquine
  3. Azithromycin
  4. Naproxen
  5. Pantoprazole
  1. Outcome (5)
  2. Clinical Resolution
  3. Lymphopenia
  4. Oxygen Saturation
  5. C-reactive Protein
  6. Hospitalization
References (2)
EUCTR2020-002123-11-ES
Clinical study in which patients are randomized to receive hydroxychloroquine vs. Cyclosporine - hydroxychloroquine to compare their efficacy in the treatment of covid-19 pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. Pneumonia associated with COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (2)
  2. Cyclosporine
  3. Hydroxychloroquine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Death
  3. Time to clinical improvement
  4. Adverse Event
  5. Inflammation
  6. SARS-CoV-2 RT-PCR
  7. Mechanical ventilation
References (1)
NCT04405310
Plasma From Covalescent Donors With Covid-19 for the Management of Patients With SARS-COV-2 Fase II and III, a Doble Center Randomized Doble Blind Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Pneumonia
  4. Severe COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (3)
  2. Hydroxychloroquine
  3. Convalescent plasma
  4. Azithromycin
  1. Comparison (3)
  2. Saline
  3. Hydroxychloroquine
  4. Azithromycin
  1. Outcome (6)
  2. Oxygen Supplementation
  3. Death
  4. Length of ICU Stay
  5. Inflammatory biomarkers
  6. Mechanical ventilation
  7. Sequential Organ Failure Assessment
References (1)
NCT04341493
Treatment With Hydroxychloroquine vs Nitazoxanide + Hydroxychloroquine in Patients With COVID-19 With Risk Factors for Poor Outcome
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  6. Child
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Nitazoxanide
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (1)
  2. Mechanical ventilation
References (2)
EUCTR2020-001333-13-FR
Dexamethasone associated with hydroxychloroquine vs. hydroxychloroquine alone for the early treatment of severe ARDS caused by COVID-19 : a randomized controlled trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Acute Respiratory Distress
  4. Severe COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Dexamethasone
  3. Hydroxychloroquine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (5)
  2. Pneumonia associated with COVID-19
  3. Death
  4. Bacteremia
  5. Mechanical ventilation
References (1)
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