NCT04307693
Randomized Controlled Clinical Trials of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  6. Child
  1. Intervention (2)
  2. Lopinavir And Ritonavir
  3. Hydroxychloroquine
  1. Comparison (0)
  1. Outcome (10)
  2. Drug Concentration
  3. Time to clinical improvement
  4. Adverse Event
  5. Death
  6. Oxygen Supplementation
  7. Viral load
  8. Admission to Intensive Care Unit
  9. NEWS2 Score
  10. Mechanical ventilation
  11. Change Of Medication
References (2)
NCT04279782
Investigation on Clinical Features of Suspected and Confirmed Patients of 2019 Novel Coronavirus Infection in Isolation Unit
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Epidemiology
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (4)
NCT04273763
Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets Combined With Standard Treatment/ Standard Treatment in Patients With Suspected and Mild Novel Coronavirus Pneumonia (COVID-19)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (1)
  2. Bromhexine Hydrochloride
  1. Comparison (0)
  1. Outcome (7)
  2. Fever
  3. Respiratory Distress
  4. Clinical deterioration
  5. Respiratory Finding
  6. Time to clinical recovery
  7. Viral clearance
  8. Adverse Event
References (3)
NCT04259892
Viral Excretion in Contact Subjects at High/Moderate Risk of Coronavirus 2019-nCoV Infection
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (7)
NCT04288713
Soliris to Stop Immune Mediated Death In Covid 19 Infected Patients. A Trial of Distal Complement Inhibition
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  1. Intervention Assignment
References (2)
NCT04304690
Sars-CoV2 Seroconversion Among Medical and Paramedical Staff in Emergency, ICU and Infectious Disease Services During the 2020 Epidemic
  1. Study Type
  2. Observational
  1. Study Aim
  2. Transmission
  3. Diagnostic/Prognostic
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
NCT04312464
Retrospective Study of Myocardial Damage in COVID-19
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Epidemiology
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
NCT04308317
Clinical Study of Tetrandrine Tablets Adjuvant Treatment With COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (6)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (1)
  2. Tetrandrine
  1. Comparison (1)
  2. Usual Care
  1. Outcome (2)
  2. Temperature
  3. Survival
References (1)
NCT04304053
Antiviral Treatment of COVID-19 Confirmed Cases and Ring Chloroquine Chemoprevention in Close Contacts: a Cluster Randomized Clinical Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Exposure to COVID-19
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (5)
  2. Hydroxychloroquine
  3. Therapeutic Intent
  4. Prophylaxis
  5. Hospital
  1. Comparison (1)
  2. Usual Care
  1. Outcome (5)
  2. Withdrawn From Research Study
  3. COVID-19
  4. Death
  5. SARS-CoV-2 RT-PCR
  6. Assessment Of Compliance With Medication Regimen
References (3)
NCT04292730
A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Moderate COVID-19 Compared to Standard of Care Treatment
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (12)
  2. Male and Female
  3. Oxygen Saturation
  4. Hospitalization
  5. Polymerase Chain Reaction
  6. COVID-19
  7. SARS-CoV-2 Virus
  8. Adult
  9. Aged (65+)
  10. Child
  1. Intervention (1)
  2. Remdesivir
  1. Comparison (1)
  2. Usual Care
  1. Outcome (2)
  2. Adverse Event
  3. Ordinal Scale
References (3)
NCT04292899
A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (10)
  2. Male and Female
  3. Hospitalization
  4. Polymerase Chain Reaction
  5. SARS-CoV-2 Virus
  6. Adult
  7. Aged (65+)
  8. Child
  1. Intervention (1)
  2. Remdesivir
  1. Comparison (1)
  2. Usual Care
  1. Outcome (3)
  2. Adverse Event
  3. Fever
  4. Oxygen Saturation
References (2)
NCT04264533
Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia: a Prospective Randomized Clinical Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Severe Acute Respiratory Infection
  4. Admission to Intensive Care Unit
  5. Adult
  6. Aged (65+)
  1. Intervention (1)
  2. Ascorbic Acid
  1. Comparison (1)
  2. Placebo
  1. Outcome (7)
  2. Length of ICU Stay
  3. Sepsis
  4. Finding Of Heart Rate
  5. Respiratory Function Finding
  6. Mechanical ventilation
  7. Vasoconstrictor
  8. Survival
References (3)
NCT04244591
Glucocorticoid Therapy for Critically Ill Patients With Severe Acute Respiratory Infections Caused by Noval Coronovirus 2019-nCoV: a Prospective, Randomized Controlled Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Intensive Care
  4. COVID-19
  5. Mechanical ventilation
  6. Adult
  7. Aged (65+)
  1. Intervention (2)
  2. Methylprednisolone
  3. Usual Care
  1. Comparison (1)
  2. Usual Care
  1. Outcome (6)
  2. PaO2 FiO2 measure
  3. All Cause Mortality
  4. Time to clinical recovery
  5. Mechanical ventilation
  6. Sequential Organ Failure Assessment Score
  7. Lower Murray lung injury score
References (2)
NCT04275245
Single Center, Single Arm, Open Clinical Study to Access Safety and Initial Efficacy of Anti-CD147 Humanized Meplazumab for Injection to Treat With 2019-nCoV Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Single Arm/Controlled Before After
  1. Intervention Assignment
  2. Not Applicable
References (4)
NCT04251871
Effects of Traditional Chinese Medicines (TCMs) on Patients With 2019-nCoV Infection: A Perspective, Open-labeled, Randomized, Controlled Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (2)
  2. Male and Female
  3. COVID-19
  1. Intervention (7)
  2. Lopinavir And Ritonavir
  3. Oxygen Therapy
  4. Traditional Chinese Medicine
  5. Interferon Alfa
  1. Comparison (0)
  1. Outcome (3)
  2. Viral shedding
  3. Time to clinical recovery
  4. Chest X-ray
References (2)
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