NCT04340349
Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. Exposure to COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Bromhexine
  4. Prophylaxis
  1. Comparison (3)
  2. Placebo
  3. Bromhexine
  4. Prophylaxis
  1. Outcome (4)
  2. SARS-CoV-2 Antibody Level
  3. SARS-CoV-2 RT-PCR
References (1)
Su 2020aa
Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
NCT04345861
Randomized Trial Assessing Efficacy and Safety of Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for Hospitalized Adults With COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Pneumonia associated with COVID-19
  6. Adult
  7. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Azithromycin
  4. Placebo
  1. Comparison (0)
  1. Outcome (10)
  2. Time to clinical improvement
  3. Electrocardiogram
  4. Clinical status
  5. Death
  6. Adverse Event
  7. Admission to Intensive Care Unit
  8. Mechanical ventilation
  9. Chest CT
  10. Duration Of Hospital Stay
  11. Ordinal Scale
References (1)
NCT04387760
Treatment of Covid-19 With Favipiravir Versus Hydroxychloroquine: a Randomized Comparator Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (1)
  2. Favipiravir
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Viral load
  3. Adverse Event
  4. Death
  5. Respiratory support
  6. Admission to Intensive Care Unit
  7. Serum lactate measurement
References (1)
Ip 2021
Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Andy 2021
Smartphone electrocardiogram for QT interval monitoring in Coronavirus Disease 2019 (COVID-19) patients treated with Hydroxychloroquine
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
NCT04355026
Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Bromhexine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Nosocomial Pneumonia
  3. Oxygen Supplementation
  4. Length of ICU Stay
  5. Mechanical ventilation
  6. Duration Of Hospital Stay
  7. Duration of Symptom
References (1)
NCT04423991
Identification of a Responsive Subpopulation to Hydroxychloroquine in COVID-19 Patients Using Machine Learning: the IDENTIFY Trial
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Not Applicable
References (2)
IRCT20200428047228N2
Hydroxychloroquine in comparison with hydroxychloroquine + azithromycin in patients with covid-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  7. Child
  1. Intervention (2)
  2. Azithromycin
  3. Hydroxychloroquine
  1. Comparison (2)
  2. Hydroxychloroquine
  3. Placebo
  1. Outcome (10)
  2. Blood Count
  3. Death In Hospital
  4. Fever
  5. Length of ICU Stay
  6. C-reactive Protein
  7. Oxygen Saturation
  8. Dyspnea
  9. Computerised Tomography
  10. Adverse Drug Reaction
  11. Duration Of Hospital Stay
References (1)
Meriglier 2020
Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Mercuro 2020a
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Mercuro 2020
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Macias 2020a
Similar incidence of Coronavirus Disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  3. Epidemiology
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
Garcia 2020s
Psychiatric Disorders and Hydroxychloroquine for Coronavirus Disease 2019 (COVID-19): a VigiBase Study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Gentry 2020
Long-term hydroxychloroquine use in patients with rheumatic conditions and development of SARS-CoV-2 infection: a retrospective cohort study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  3. Prevention
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
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