NCT04385264
#StayHome: Efficacy of Early Hydroxychloroquine in Outpatients to Reduce Secondary Hospitalisation and Household Transmission of COVID-19 in Switzerland: A Double-blind, Randomised, Placebo-controlled Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
Tang 2020m
Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. COVID-19
  3. Chest CT
  4. SARS-CoV-2 RT-PCR
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Oral
  1. Comparison (1)
  2. Usual Care
  1. Outcome (2)
  2. Adverse Event
  3. Viral nucleic acid test
References (1)
Mercuro 2020
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
NCT04318015
Chemoprophylaxis With Hydroxychloroquine in Healthcare Personnel in Contact With COVID-19 Patients: A Randomized Controlled Trial (PHYDRA Trial)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  3. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
NCT04315896
Hydroxychloroquine Treatment for Severe COVID-19 Respiratory Disease: Randomised Clinical Trial (HYDRA Trial)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
NCT04333654
A Phase 1b, Randomized, Double-blinded, Placebo-controlled Study of Hydroxychloroquine in Outpatient Adults With COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (0)
  1. Comparison (0)
  1. Outcome (0)
References (1)
IRCT20190122042450N4 // U07
The effect of hydroxychloroquine to prevent coronavirus disease
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  3. Health Services Research
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
NCT04345861
Randomized Trial Assessing Efficacy and Safety of Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for Hospitalized Adults With COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Pneumonia associated with COVID-19
  6. Adult
  7. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Azithromycin
  4. Placebo
  1. Comparison (0)
  1. Outcome (10)
  2. Time to clinical improvement
  3. Electrocardiogram
  4. Clinical status
  5. Death
  6. Adverse Event
  7. Admission to Intensive Care Unit
  8. Mechanical ventilation
  9. Chest CT
  10. Duration Of Hospital Stay
  11. Ordinal Scale
References (1)
IRCT20150808023559N20 // U07
Efficacy of hydroxychloroquine plus favipiravir drug regimen in comparison with hydroxychloroquine plus kaletra in hospitalized patients with COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (2)
  2. Favipiravir
  3. Hydroxychloroquine
  1. Comparison (2)
  2. Lopinavir And Ritonavir
  3. Hydroxychloroquine
  1. Outcome (2)
  2. Death
  3. Duration Of Hospital Stay
References (1)
Saleh 2020
The Effect of Chloroquine, Hydroxychloroquine and Azithromycin on the Corrected QT Interval in Patients with SARS-CoV-2 Infection
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
NCT04340349
Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. Exposure to COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Bromhexine
  4. Prophylaxis
  1. Comparison (3)
  2. Placebo
  3. Bromhexine
  4. Prophylaxis
  1. Outcome (4)
  2. Antibody to SARS-CoV-2
  3. SARS-CoV-2 RT-PCR
References (1)
NCT04394442
Use of Hydroxychloroquine in Patients With COVID-19: A Randomized Controlled Clinical Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. SARS-CoV-2 RT-PCR
  5. Adult
  6. Aged (65+)
  1. Intervention (1)
  2. Hydroxychloroquine
  1. Comparison (0)
  1. Outcome (5)
  2. Death
  3. Viral clearance
  4. Afebrile
  5. Mechanical ventilation
  6. Duration Of Hospital Stay
References (1)
NCT04371523
Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers (PROVIDE): A Parallel Randomized Controlled Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (5)
  2. Male and Female
  3. Healthcare Professional
  4. Adult
  1. Intervention (1)
  2. Hydroxychloroquine
  1. Comparison (1)
  2. Placebo
  1. Outcome (9)
  2. Adverse Event
  3. Death
  4. Hospitalization
  5. Length of ICU Stay
  6. COVID-19
  7. Intubation
  8. Mechanical ventilation
  9. Admission to Intensive Care Unit
  10. Duration Of Hospital Stay
References (1)
NCT04355026
Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Bromhexine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Nosocomial Pneumonia
  3. Oxygen Supplementation
  4. Length of ICU Stay
  5. Mechanical ventilation
  6. Duration Of Hospital Stay
  7. Duration of Symptom
References (1)
Dousa 2020
SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: implications for prophylaxis
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case Report
  1. Intervention Assignment
  2. Not Applicable
References (1)
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