NCT04362332
An Open Label Cluster Randomized Controlled Trial of Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. NEWS2 Score
  6. Adult
  7. Aged (65+)
  1. Intervention (4)
  2. Chloroquine
  3. Supportive care
  4. Hydroxychloroquine
  1. Comparison (1)
  2. Support
  1. Outcome (5)
  2. Adverse Event
  3. Treatment discontinued
  4. Death
  5. NEWS2 Score
  6. Admission to Intensive Care Unit
References (1)
References (1)
NCT04355026
Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Bromhexine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Nosocomial Pneumonia
  3. Oxygen Supplementation
  4. Length of ICU Stay
  5. Mechanical ventilation
  6. Duration Of Hospital Stay
  7. Duration of Symptom
References (1)
References (1)
NCT04354441
Randomized Trial Evaluating Effect of Outpatient Hydroxychloroquine on Reducing Hospital Admissions in Pregnant Women With SARS-CoV-2 Infection: HyPreC Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (6)
  2. Female
  3. COVID-19
  4. Pregnant
  5. Adult
  1. Intervention (1)
  2. Hydroxychloroquine Sulfate
  1. Comparison (1)
  2. Placebo
  1. Outcome (16)
  2. Birth Weight
  3. Delivery mode
  4. Gestational Age
  5. Gender
  6. Miscarriage
  7. Adverse Event
  8. Jaundice
  9. Epidural Anesthesia
  10. Labour Induction
  11. Hospitalization
  12. Stillbirth
  13. Symptom severity
  14. Augmentation Of Labor
  15. Resuscitation
  16. Admission to Intensive Care Unit
  17. Cesarean Section
References (1)
NCT04371406
Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients: Randomized Controlled Trial: MG-COVID
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (4)
  2. Azithromycin
  3. Hydroxychloroquine
  4. General Practitioner
  1. Comparison (1)
  2. Placebo
  1. Outcome (14)
  2. Serious Adverse Event
  3. Death
  4. Withdrawn From Research Study
  5. Time to clinical recovery
  6. Adverse Event
  7. Viral load
  8. Clinical status
  9. Hospitalization
  10. Oxygen Saturation
  11. Mechanical ventilation
  12. Oxygen Therapy
  13. Admission to Intensive Care Unit
  14. Antibiotic Therapy
References (1)
Eveleens 2021
Effect of hydroxychloroquine on the cardiac ventricular repolarization - a randomized clinical trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
Andy 2021
Smartphone electrocardiogram for QT interval monitoring in Coronavirus Disease 2019 (COVID-19) patients treated with Hydroxychloroquine
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Ip 2021
Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
NCT04330144
A Study of Hydroxychloroquine as Post Exposure Prophylaxis for SARS-CoV-2(HOPE Trial)
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. Exposure to COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Prophylaxis
  1. Comparison (1)
  2. Usual Care
  1. Outcome (1)
  2. COVID-19
References (2)
NCT04423991
Identification of a Responsive Subpopulation to Hydroxychloroquine in COVID-19 Patients Using Machine Learning: the IDENTIFY Trial
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Not Applicable
References (2)
IRCT20200428047228N2
Hydroxychloroquine in comparison with hydroxychloroquine + azithromycin in patients with covid-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  7. Child
  1. Intervention (2)
  2. Azithromycin
  3. Hydroxychloroquine
  1. Comparison (2)
  2. Hydroxychloroquine
  3. Placebo
  1. Outcome (10)
  2. Blood Count
  3. Death In Hospital
  4. Fever
  5. Length of ICU Stay
  6. C-reactive Protein
  7. Oxygen Saturation
  8. Dyspnea
  9. Computerised Tomography
  10. Adverse Drug Reaction
  11. Duration Of Hospital Stay
References (1)
NCT04370782
A Randomized Study Evaluating the Safety and Efficacy of Hydroxychloroquine and Zinc in Combination With Either Azithromycin or Doxycycline for the Treatment of COVID-19 in the Outpatient Setting
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Co-morbid conditions
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (6)
  2. Zinc
  3. Hydroxychloroquine
  4. Doxycycline
  5. Azithromycin
  1. Comparison (0)
  1. Outcome (8)
  2. Length of ICU Stay
  3. Hospitalization
  4. Adverse Drug Reaction
  5. Prolonged QT Interval
  6. Symptom severity
  7. Emergency Department Patient Visit
  8. Mechanical ventilation
  9. Duration of Symptom
References (1)
Meriglier 2020
Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
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