NCT04858633
Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19 in Asymptomatic Individual at Risk for SARS-CoV-2 Infection-A Randomized Control Clinical Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
NCT04354441
Randomized Trial Evaluating Effect of Outpatient Hydroxychloroquine on Reducing Hospital Admissions in Pregnant Women With SARS-CoV-2 Infection: HyPreC Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (6)
  2. Female
  3. COVID-19
  4. Pregnant
  5. Adult
  1. Intervention (1)
  2. Hydroxychloroquine Sulfate
  1. Comparison (1)
  2. Placebo
  1. Outcome (16)
  2. Birth Weight
  3. Delivery mode
  4. Gestational Age
  5. Gender
  6. Miscarriage
  7. Adverse Event
  8. Jaundice
  9. Epidural Anesthesia
  10. Labour Induction
  11. Hospitalization
  12. Stillbirth
  13. Symptom severity
  14. Augmentation Of Labor
  15. Resuscitation
  16. Admission to Intensive Care Unit
  17. Cesarean Section
References (1)
NCT04370782
A Randomized Study Evaluating the Safety and Efficacy of Hydroxychloroquine and Zinc in Combination With Either Azithromycin or Doxycycline for the Treatment of COVID-19 in the Outpatient Setting
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Co-morbid conditions
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (6)
  2. Zinc
  3. Hydroxychloroquine
  4. Doxycycline
  5. Azithromycin
  1. Comparison (0)
  1. Outcome (8)
  2. Length of ICU Stay
  3. Hospitalization
  4. Adverse Drug Reaction
  5. Prolonged QT Interval
  6. Symptom severity
  7. Emergency Department Patient Visit
  8. Mechanical ventilation
  9. Duration of Symptom
References (1)
NCT04860284
The Efficacy and Safety of Hydroxychloroquine for the Treatment Of Non-Severe COVID-19 in Adults in Uganda: A Randomized Open Label Phase II Clinical Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (2)
NCT04369742
Treating COVID-19 With Hydroxychloroquine: A Multicenter Randomized, Double-blind, Placebo-controlled Clinical Trial in Hospitalized Adults
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Oral
  1. Comparison (2)
  2. Calcium Citrate
  3. Oral
  1. Outcome (31)
  2. Adverse Event
  3. Aspartate Aminotransferase level
  4. Creatinine level
  5. Treatment discontinued
  6. T-cell count
  7. Bilirubin Total
  8. Death
  9. White blood cell count procedure
  10. Fever
  11. Hemoglobin Finding
  12. Cytokine level
  13. Disease Progression
  14. Glucose measurement
  15. C-reactive Protein
  16. Prolonged QT Interval
  17. Antibody Titer
  18. Platelet Count
  19. Invasive Mechanical Ventilation
  20. Lactic Dehydrogenase level
  21. Low Blood Pressure
  22. Alanine Aminotransferase
  23. Serious Adverse Event
  24. Oxygen Supplementation
  25. Non-rebreathing Oxygen Face Mask
  26. Extracorporeal Membrane Oxygenation
  27. World Health Organization Ordinal Scale
  28. Covid-19 RT-PCR testing
  29. Interleukin-6
  30. Admission to Intensive Care Unit
  31. Continuous Positive Airway Pressure Ventilation
  32. Duration Of Hospital Stay
References (2)
NCT04362332
An Open Label Cluster Randomized Controlled Trial of Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. NEWS2 Score
  6. Adult
  7. Aged (65+)
  1. Intervention (4)
  2. Chloroquine
  3. Supportive care
  4. Hydroxychloroquine
  1. Comparison (1)
  2. Support
  1. Outcome (5)
  2. Adverse Event
  3. Treatment discontinued
  4. Death
  5. NEWS2 Score
  6. Admission to Intensive Care Unit
References (1)
NCT04371406
Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients: Randomized Controlled Trial: MG-COVID
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (4)
  2. Azithromycin
  3. Hydroxychloroquine
  4. General Practitioner
  1. Comparison (1)
  2. Placebo
  1. Outcome (14)
  2. Serious Adverse Event
  3. Death
  4. Withdrawn From Research Study
  5. Time to clinical recovery
  6. Adverse Event
  7. Viral load
  8. Clinical status
  9. Hospitalization
  10. Oxygen Saturation
  11. Mechanical ventilation
  12. Oxygen Therapy
  13. Admission to Intensive Care Unit
  14. Antibiotic Therapy
References (1)
NCT04355052
An Open-Label Study to Compare the Efficacy, Safety, and Tolerability of Hydroxychloroquine Combined With Azithromycin Compared to Hydroxychloroquine Combined With Camostat Mesylate and to no Treatment in Hospitalized Patients Suffering From a Mild or Moderate SARS CoV 2 Virus
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Single Arm/Controlled Before After
  1. Intervention Assignment
  2. Randomised
References (1)
Su 2020aa
Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Marme 2022
Adverse Effects of Hydroxychloroquine in COVID-19 Patients- A Review of Eudravigilance Database
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Other
  1. Intervention Assignment
  2. Not Applicable
References (1)
NCT04345861
Randomized Trial Assessing Efficacy and Safety of Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for Hospitalized Adults With COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Pneumonia associated with COVID-19
  6. Adult
  7. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Azithromycin
  4. Placebo
  1. Comparison (0)
  1. Outcome (10)
  2. Time to clinical improvement
  3. Electrocardiogram
  4. Clinical status
  5. Death
  6. Adverse Event
  7. Admission to Intensive Care Unit
  8. Mechanical ventilation
  9. Chest CT
  10. Duration Of Hospital Stay
  11. Ordinal Scale
References (1)
NCT04355026
Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Bromhexine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Nosocomial Pneumonia
  3. Oxygen Supplementation
  4. Length of ICU Stay
  5. Mechanical ventilation
  6. Duration Of Hospital Stay
  7. Duration of Symptom
References (1)
NCT04344379
Randomized Multicenter Study Evaluating the Efficacy of Azithromycin and Hydroxychloroquine in the Prevention of SARS-CoV-2 Infection in the Hospital Population Exposed to Virus
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
References (1)
Ip 2021
Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Andy 2021
Smartphone electrocardiogram for QT interval monitoring in Coronavirus Disease 2019 (COVID-19) patients treated with Hydroxychloroquine
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
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