NCT04340349
Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (7)
  2. Male and Female
  3. Exposure to COVID-19
  4. Adult
  5. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Bromhexine
  4. Prophylaxis
  1. Comparison (3)
  2. Placebo
  3. Bromhexine
  4. Prophylaxis
  1. Outcome (4)
  2. SARS-CoV-2 Antibody
  3. SARS-CoV-2 RT-PCR
References (1)
Ip 2021
Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Garcia 2020s
Psychiatric Disorders and Hydroxychloroquine for Coronavirus Disease 2019 (COVID-19): a VigiBase Study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
Su 2020aa
Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
NCT04345861
Randomized Trial Assessing Efficacy and Safety of Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for Hospitalized Adults With COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Pneumonia associated with COVID-19
  6. Adult
  7. Aged (65+)
  1. Intervention (4)
  2. Hydroxychloroquine
  3. Azithromycin
  4. Placebo
  1. Comparison (0)
  1. Outcome (10)
  2. Time to clinical improvement
  3. Electrocardiogram
  4. Clinical status
  5. Death
  6. Adverse Event
  7. Admission to Intensive Care Unit
  8. Mechanical ventilation
  9. Chest CT
  10. Duration Of Hospital Stay
  11. Ordinal Scale
References (1)
Gentry 2020
Long-term hydroxychloroquine use in patients with rheumatic conditions and development of SARS-CoV-2 infection: a retrospective cohort study
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  3. Prevention
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
Meriglier 2020
Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
Kim 2020ac
Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
Mercuro 2020
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
NCT04355026
Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (8)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  1. Intervention (2)
  2. Hydroxychloroquine
  3. Bromhexine
  1. Comparison (1)
  2. Hydroxychloroquine
  1. Outcome (6)
  2. Nosocomial Pneumonia
  3. Oxygen Supplementation
  4. Length of ICU Stay
  5. Mechanical ventilation
  6. Duration Of Hospital Stay
  7. Duration of Symptom
References (1)
Ruiz 2020g
Hydroxychloroquine lung pharmacokinetics in critically ill patients infected with COVID-19
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (1)
IRCT20200428047228N2
Hydroxychloroquine in comparison with hydroxychloroquine + azithromycin in patients with covid-19
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (9)
  2. Male and Female
  3. Hospitalization
  4. COVID-19
  5. Adult
  6. Aged (65+)
  7. Child
  1. Intervention (2)
  2. Azithromycin
  3. Hydroxychloroquine
  1. Comparison (2)
  2. Hydroxychloroquine
  3. Placebo
  1. Outcome (10)
  2. Blood Count
  3. Death In Hospital
  4. Fever
  5. Length of ICU Stay
  6. C-reactive Protein
  7. Oxygen Saturation
  8. Dyspnea
  9. Computerised Tomography
  10. Adverse Drug Reaction
  11. Duration Of Hospital Stay
References (1)
Mercuro 2020a
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
  1. Study Type
  2. Observational
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
NCT04371523
Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers (PROVIDE): A Parallel Randomized Controlled Trial
  1. Study Type
  2. Interventional
  1. Study Aim
  2. Prevention
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
  1. Population (5)
  2. Male and Female
  3. Healthcare Professional
  4. Adult
  1. Intervention (1)
  2. Hydroxychloroquine
  1. Comparison (1)
  2. Placebo
  1. Outcome (9)
  2. Adverse Event
  3. Death
  4. Hospitalization
  5. Length of ICU Stay
  6. COVID-19
  7. Intubation
  8. Mechanical ventilation
  9. Admission to Intensive Care Unit
  10. Duration Of Hospital Stay
References (1)
Lopez 2020g
Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: preliminary Results
  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Treatment and Management
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
References (2)
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