Resting energy expenditure measured by indirect calorimetry: ventilated Covid-19 patients are normometabolic

Rationale: Indirect calorimetry is gold standard to assess Resting Energy Expenditure (1). The aim was to determine REE and objectify evolution of metabolism over time in critically ill, ventilated COVID-19 patients. Methods: We performed indirect calorimetry during the course of disease. Extra safety measures to protect healthcare practitioners were taken. REE, Respiratory Quotient, VO2, VCO2 and their variability were monitored. Results: 19 IC's were performed in 6 patients between day1 and day 26 of ventilation. Mean age: 63y (range 52-74), 5 male patients, survival 67%. Average BMI was 30.3. On average, the Energy Expenditure was 2021kcal/day or 21 kcal/kg/day. [Formula presented] REE in kcal/kg/day. Horizontal axis: ventilation day. Vertical axis: patient number Conclusion: Although contra-indicated by some (2), we performed IC in COVID-19 patients and found a mean REE of 2021 kcal/day or 21 kcal/kg/day. The evolution over time showed variable findings but no ‘ebb and flood phases’. References: 1: ESPEN guideline on clinical nutrition in the intensive care unit.Singer P et al. Clin Nutr. 2019 Feb;38(1):48-79. 2: Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID-19). Martindale R et al.JPEN J Parenter Enteral Nutr. 2020 May 27:10.1002/jpen.1930. Disclosure of Interest: None declared