Cochrane COVID-19 Study Register
Keser 2020

Osteosarcopenic adiposity in croatian nursing home residents: indications for increased susceptibility to Covid-19 and possible ways for curtailment

  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  3. Epidemiology
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable

Osteosarcopenic adiposity in croatian nursing home residents: indications for increased susceptibility to Covid-19 and possible ways for curtailment

Keser I, Cvijetic S, Jurasovic J, Baric IC, Knezovic M, Boschiero D, Ilich JZ
Rationale: Osteosarcopenic adiposity (OSA) is characterized by bone and muscle loss with increased adiposity either as overweight/obesity or redistributed and/or infiltrated fat in bone and muscle. OSA was related to metabolic disorders, poor nutrition and declined physical function. There are no studies evaluating OSA in nursing home residents (NHR) suffering from multiple comorbidities. With recognized vulnerability of NHR to COVID-19 and OSA being a potential risk factor, we aimed to determine prevalence of OSA in that population. We also explored OSA association with low-grade chronic inflammation (LGCI) and dietary parameters. Methods: Participants were n=84 NHR (81.2±6.8y; BMI, 29.2±5.0 kg/m2), 82.1% females, with multiple comorbidities. Advanced bio-impedance devices, BIA-ACC and PPG-Stress Flow (BioTekna®, Marcon-Venice, Italy), were used to determine total body bone mass (kg, T-score); muscle mass (kg, S-score); fat mass (kg and % of body weight), extracellular water (ECW%) and phase angle, as indicators of LGCI. Dietary intake was estimated by 24-hour recall. Protocol was approved by the Institutional review board and each subject signed the informed consent. Results: OSA was identified in 66.7% women and 40.0% men. Phase angle was low (0.73±0.70, normal >3.5) and ECW% was elevated (53.7±5.4%, normal <40%). Positive correlation existed between phase angle and energy, protein, total fat, PUFA, phosphorus and vitamin C intake, all p<0.05. Protein intake positively correlated with S-score and muscle mass, p<0.05. Conclusion: Our results show very high prevalence of OSA among NHR. More attention should be paid to body composition and OSA in that population, particularly in time of COVID-19. A personalized diet and physical activities recommended for OSA could prevent/manage OSA, making nursing homes residents less susceptible to COVID-19 infections. References: Ilich JZ, Gilman JC, Cvijetic S, Boschiero D. Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation. Nutrients, 2020;12(4):E989. Kelly JO, Gilman JC, Boschiero D, Ilich JZ. Osteosarcopenic obesity: Current knowledge, revised identification criteria and treatment principles. Nutrients, 2019; 11 (4),. Disclosure of Interest: None declared