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Cochrane COVID-19 Study Register
Study record
IRCT20130812014333N164First Published: 2021 Aug 26Updated Date: 2021 Aug 26

Investigation of the effects of the exosomes on patients with COVID-19

  1. Study Type
  2. Interventional
  1. Study Aim
  2. Treatment and Management
  1. Study Design
  2. Parallel/Crossover
  1. Intervention Assignment
  2. Randomised
Reference record

Investigation of the effects of the exosomes on patients with COVID-19

Kermanshah University of Medical Sciences
Trial registry record
No Results
INTERVENTION: Intervention 1: The intervention group in addition to the usual treatment will receive single-dose exosomes (one billion exosomes per kilogram) twice on two consecutive days by injection. Regarding the pharmaceutical company, it has not a pharmaceutical company, separation and processing are done in the cell culture laboratory of the Biological Research Center of Kermanshah University of Medical Sciences. Intervention 2: The control group, in addition to the placebo(50cc dextrose saline), will receive the usual medicine (Recigen; 12000000 unit every other day till 5 dosages, Kaletra, sevodak: daily for 5 days, high dose dexamethasone for 7 days with tapering). CONDITION: COVID-19. ; COVID-19 U07.1 PRIMARY OUTCOME: Ferritin. Timepoint: 2 to 3 days after injection,daily for two weeks. Method of measurement: Using a blood test and Chemiluminescence immunoassay method. Neutrophil to lymphocyte ratio. Timepoint: 2 to 3 days after injection,daily for two weeks. Method of measurement: Using a blood test (To determine the percentage of neutrophils and lymphocytes, the optical method or light microscope and Giemsa staining is used). Oxygen saturation. Timepoint: 2 to 3 days after injection,daily for two weeks. Method of measurement: Using a pulse oximeter. INCLUSION CRITERIA: Infected patients with Corona virus based on CRISPR test (PCR) Diagnosis of acute respiratory syndrome according to Berlin criteria Requires oxygenation or confirmed pneumonia by radiologically or CT Oxygen uptake concentration Progression of of pulmonary edema more than 50% within 24-48 hours Mild to moderate pneumonia caused by a new coronavirus