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Cochrane COVID-19 Study Register
Study record
Senol 2022eFirst Published: 2022 Nov 23Updated Date: 2022 Nov 23

The ability of D-dimer, albumin, and D-Dimer/albumin ratio to predict in-hospital mortality and intensive care unit admission in COVID-19 patients admitted to the emergency department

  1. Study Type
  2. Observational
  1. Study Aim
  2. Diagnostic/Prognostic
  1. Study Design
  2. Case series/Case control/Cohort
  1. Intervention Assignment
  2. Not Applicable
Reference record

The ability of D-dimer, albumin, and D-Dimer/albumin ratio to predict in-hospital mortality and intensive care unit admission in COVID-19 patients admitted to the emergency department

Senol A
Journal article
Report Results
OBJECTIVES: COVID-19 can also cause multi-organ failure or severe pneumonia. Therefore, new biomarkers are being investigated for rapid diagnosis, early treatment and reduced mortality rates. In this study, D-dimer and albumin were looked at from a different perspective. BACKGROUND: We think that D-dimer/Albumin ratio (DAR), D-dimer and albumin may be parameters that can be used to predict in-hospital mortality and intensive care unit admission in COVID-19 patients. METHODS: The patients included in the study were divided into 2 groups according to their hospitalization status in the service and intensive care unit. These two groups were compared in terms of DAR, other laboratory data and in-hospital mortality. RESULTS: The primary findings we obtained are as follows: (1) DAR and D-dimer values are higher in patients who died in-hospital, and albumin values are lower than those who survived; (2) D-dimer and DAR median values are significantly higher in the intensive care group than in the service group. Albumin was significantly lower in the intensive care group; (3) D-dimer, albumin and DAR predicting in-hospital mortality, respectively: D-Dimer's sensitivity 56 % and specificity 57 %, albumin's sensitivity 70 % and specificity 53 %, DAR's sensitivity 56 %, specificity is 58 %; (4) The parameter with the highest predictive power for intensive care admission is albumin. CONCLUSION: Although albumin had the highest sensitivity values in determining mortality or predicting intensive care admission in our study, we think that D-dimer and DAR may be other parameters to be used to predict intensive care admission and in-hospital mortality (Tab. 5, Fig. 2, Ref. 19) Keywords: COVID-19, albumin, D-dimer, mortality, D-dimer/albumin